ABSTRACT
Objective To identify predictors of 30-day survival in elderly patients with COVID-19. Methods Retrospective cohort study including COVID-19 patients≥65 years old hospitalized in 6 European sites (January 2020-May 2021). Demographics, comorbidities, clinical characteristics and outcomes were collected. A predictive score (FLAMINCOV) was developed using logistic regression. Regression coefficients were used to calculate the score. External validationina cohort including elderly patients from a major COVID-19 center in Israel was performed. Discrimination was evaluated by the area under the receiver operating characteristic curve (AUC)in the derivation and validation cohorts. Survival risk groups based on the score were derived and applied to the validation cohort. Results Among 3010 patients included in the derivation cohort, 30-day survival was 74.5% (2242/3010). Intensive care unit (ICU) admission rate was 7.6% (228/3010).The model predicting survival included independent functional status (OR 4.87, 95%CI 3.93-6.03), SpO2/FiO2 ratio>235 (OR 3.75, 95%CI 3.04-4.63), C-reactive protein<14 mg/dl (OR 2.41, 95%CI 1.91-3.04), creatinine<1.3 (OR 2.02, 95%CI 1.62-2.52) mg/dl and absence of fever (OR 1.34, 95%CI 1.09-1.66). The score was validated in 1174 patients. The FLAMINCOV score ranges from 0 to 15 and showed good discrimination in the derivation (AUC 0.79, 95%CI 0.77–0.81, p<0.001) and validation cohort (AUC 0.79, 95%CI 0.76–0.81, p<0.001). Thirty-day survival ranged from 39.4% (203/515) to 95.3% (634/665)across four risk groups according to scorequartiles in the derivation cohort. Similar proportions were observed in the validation set.. Conclusions The FLAMINCOV score identifying elderly with higher or lower chances of survival may allow better triage and management, including ICU admission/exclusion.
ABSTRACT
The current experiment was performed to find the potential effect of inorganic and organic forms of zinc (Zn) on growth, intestinal histomorphology, immune response, and paraoxonase (PON1) activity in broiler. In this experiment, a total of 450 broiler chickens were assigned to four experimental and control groups. The birds received organic Zn at the rate of 50 mg/kg (OZ-50) and 60 mg/kg (OZ-60) or inorganic Zn at the rate of 50 mg/kg (IZ-50) and 60 mg/kg (IZ-60) for an experimental period of 30 days. Significantly (P < 0.05) higher feed consumption, body weight, feed conversion ratio, and production efficiency factor (PEF) were recorded in OZ-50. Similarly, antibody titer against infectious bronchitis (IB) and PON1 activity was higher (P < 0.05) in OZ-50 compared with the control group. In addition, significantly (P < 0.05) higher villus dimensions and goblet cell count were recorded for the group OZ-50 compared with other treatments. It was concluded that the organic form of Zn was superior in improving the growth, histological features of intestines, humoral response, and PON1 activity in broiler.